The press conference, which will kick-off at 1pm PDT (8pm GMT) on June 13 after a 30-minute pre-show warm up, will be live streamed on Ubisoft's YouTube and Twitch channels.
They'll also be an Ubisoft Lounge for 1,700 fans to attend and play the games Ubisoft is unveiling, more of which you can see in Ubisoft's teaser trailer below.
Ubisoft is also celebrating its 30-year anniversary at the show, making this an extra special E3 for the French company.
"Our industry has evolved so much in the past 30 years, but what hasn’t changed is my love and respect for the limitless passion and talent of developers and players alike,” said Yves Guillemot, co-founder and CEO, Ubisoft.
“The video game industry continues to enjoy strong momentum, with powerful new platforms that enable more creativity, expression and imagination."
"More than ever, video games are showing how they will shape the future of entertainment. I can’t wait to be at E3 and see what the future has in store.”
Video: We predict the highlights of E3 2016
Ubisoft's VR-only game, Eagle Flight, will also feature heavily. In it, players experience life as an eagle and compete in 3v3 multiplayer battles.