The social network said it had responded to users who'd complained that the current Timeline layout, with posts and activities appearing simultaneously in two columns across the page, was hard to follow.
The revamped profile page, which will begin rolling out to users today, clearly segregates new posts (status updates, links, photos) to the site on the right hand side of the page.
Meanwhile, users' recent activity from apps like Instagram and Spotify, along with the Friends and Photos sections will appear exclusively on the left side of the Timeline, beneath the About listing.
In a post on the Facebook Newsroom blog, Rose Yao wrote: "We heard from you that the current timeline layout is sometimes hard to read. Starting today, all posts are on the right side of your timeline, with photos, music and other recent activity on the left."
Meanwhile, the About section itself is also part of the revamp, allowing folks to add their favourite movies, books and albums, while also sharing what they're currently watching, reading or listening to.
As well as organising, users can also use the about section to customise which apps appear within your Timeline. For example you can add or remove an Instagram section by visiting the Activity Log.
Yao, who is the project head for Facebook Open Graph, added: "Now it’s easier to organize the things you care about on your About page. Redesigned sections give you one place to add music, movies, TV shows and books that interest you, alongside your photos and friends.
"If you’re a movie buff, you can add your favorites to your movies section or use apps like Flixster and Netflix to share what you’re watching."
The revamp comes less than a week after the company unveiled its brand new News Feed, which also brought a cleaner, more focused design with dedicated feeds for photos, likes, music and more.