The title is now available on the PlayStation Store for £15.99/$20. It appears THQ Nordic has spruced the game up somewhat for modern displays, as it now runs at a higher resolution.
In addition to slightly nicer visuals, you can also gain trophies not seen in the original release, much like other PS2 classics on the platform.
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Developed by the now defunct Pandemic Studios, Destroy All Humans first launched for PS2 back in 2005.
Taking place in the 1960s, you play as Crypto, a foul-mouthed grey alien with the goal of invading and enslaving our planet.
You could anal probe to your heart's content or jump into a flying saucer and set the United States aflame.
It proved to be a fun semi-open world adventure back in its day, and still holds up by modern standards.
Have you been playing any PS2 classics on PS4? Let us know in the comments.