The combination of three M- and 12 G-keys means that you shouldn't suffer any lack of customizable buttons. In all likelihood those three M-keys will end up assigned to different games - M1 for Team Fortress 2, M2 for Bad Company 2, M3 for Modern Warfare 2, in my case.
Usefully, the G110's configuration utility lets you set a different backlight colour - that can be made by mixing red and blue - for each of these keys, just so you can be sure which is activated at a given point. Also useful if you tend to attach the same peripherals to multiple computers frequently (and who doesn't?), profile settings are stored on the G110, so you can take your preferences with you to a mate's house, or LAN centre, should you be so inclined.
The supplied wrist wrest attaches and detaches easily enough and extrudes far enough to actually be of use. It's ultimately just a piece of plastic, though, so it’s not the most comfortable thing to slump your lower arm on for long periods of time. If you need a wrest, you're better off buying a decent ergonomic one as it'll be better for you in the long run.
On the subject of comfort, it must be said that the G110's keys have an excellent action. The travel is fairly deep, and slightly cushioned, encouraging firm strikes. It’s reminiscent of using a typewriter, with all the brilliantly solid feedback that entails - I definitely like it. Admittedly if you're bit of a pansy, or you've become used to typing on a particularly shallow keyboard, the firmness required to ensure key presses are registered could take a bit of getting used to, but I've no complaints.
A tactile feel is always welcome in games. There's nothing more frustrating than feeling that your out-of-game equipment is ruining your in-game performance but alas with the G110 my seeming inability to be anything but terrible at Bad Company 2 can't be blamed on this keyboard. Spending £70 on a G110 isn’t going to make you a better gamer, but it won't make you worse - a criticism I reserve for the horrible Razer Lycosa.
The Logitech G110 may be stripped down versus the G19, but it doesn't eschew the gimmicks, namely its USB audio processing, entirely, no doubt contributing to its hard-to-ignore £70 price tag. Nonetheless, the sturdy build quality and great tactile feel make that a worthwhile investment.